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Abstract #3468

Direct Estimation of pre-contrast T1 for DCE-MRI

Zhibo Zhu1, Yannick Bliesener1, R. Marc Lebel2,3, and Krishna Shrinivas Nayak1
1Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, United States, 2Global MR Applications & Workflow, GE Healthcare, Calgary, AB, Canada, 3Radiology, University of Calgary, Calgary, AB, Canada

Quantitative DCE-MRI requires pre-contrast T1 mapping with matching resolution and coverage. Recent studies have shown that sparse sampling and constrained reconstruction can be applied to both DCE-MRI and pre-contrast T1 mapping with the variable flip angle (VFA) approach. Here, we demonstrate and evaluate direct estimation of T1 from sparsely sampled VFA raw data. In healthy subjects, we demonstrate superior T1 estimation compared with prior methods at subsampling factors >10.

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