Abstract #3486

Myelin Damage in Chronic Multiple sclerosis lesions: QSM versus Phase imaging

Weiyuan Huang^1,2, Thanh D Nguyen¹, Elizabeth Sweeney³, Xianfu Luo¹, Yi Wang^1,4, and Susan A Gauthier⁵

¹Radiology, Weill Cornell Medicine, New York, NY, United States, ²Radiology, Hainan General Hospital, Haikou, China, ³Healthcare Policy and Research, Weill Cornell Medicine, New York, NY, United States, ⁴Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, United States, ⁵Neurology, Weill Cornell Medicine, New York, NY, United States

The aim of this study was to compare differences in myelin damage among chronic MS lesions identified on QSM as compared to phase imaging. A total of 307 lesions were classified into five categories based upon QSM and Phase features, which included the presence of a hyperintense rim on QSM or hypointense rim on phase. MWF was used to assess myelin damage. Of those lesions identified to have a rim on phase, only those with a rim on QSM demonstrated the lowest MWF. QSM imaging may be more sensitive than phase imaging in detecting myelin damage in MS lesions.

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