The aim of this study was to compare differences in myelin damage among chronic MS lesions identified on QSM as compared to phase imaging. A total of 307 lesions were classified into five categories based upon QSM and Phase features, which included the presence of a hyperintense rim on QSM or hypointense rim on phase. MWF was used to assess myelin damage. Of those lesions identified to have a rim on phase, only those with a rim on QSM demonstrated the lowest MWF. QSM imaging may be more sensitive than phase imaging in detecting myelin damage in MS lesions.