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Abstract #3666

Evaluation of a standardized quantitative method of brain Iron based on quantitative susceptibility mapping and Brainnetome Atlas

Dongxue Li1, Bin Dai1, Zhenliang Xiong1, Xianchun Zeng1, Lisha Nie2, Pu-Yeh Wu2, and Rongpin Wang1
1Department of Radiology, Guizhou Provincial People's Hospital, Guiyang, China, 2GE Healthcare, MR Research, Beijing, China

Delineating the region of interest manually to obtain the magnetic susceptibility values from quantitative susceptibility mapping (QSM) for diagnosis of neurological diseases is a common method. However, this approach is time-consuming and may be inaccurate due to human error. Here we introduced a standardized brain region susceptibility quantification procedure based on QSM and Brainnetome Atlas. Our results show that this method has high accuracy in measuring brain iron content. Based on this method, we found that the content of brain iron tends to increase with age. Additionally, magnetic susceptibility values of partial brain regions have sex differences should be noted.

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