Abstract #3673

Evaluation of quantitative MRI parameters reproducibility across a major scanner upgrade: the example of T1

Ratthaporn Boonsuth¹, Marco Battiston¹, Francesco Grussu^1,2, Marios C. Yiannakas¹, Torben Schneider³, Rebecca S. Samson¹, Ferran Prados¹, and Claudia A. M. Gandini Wheeler-Kingshott^1,4,5

¹NMR research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, ²Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, ³Philips Healthcare, Guildford, Surrey, United Kingdom, ⁴Brain MRI 3T Research Centre, IRCCS Mondino Foundation, Pavia, Italy, ⁵Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy

Major MRI scanner upgrades are generally required to improve performance and image quality; however, they can also potentially introduce systematic changes in quantitative MRI (qMRI) metrics and affect their accuracy and precision. To date the evaluation of the effect of scanner upgrades has focussed mainly on volumetric measurements, whereas the effect on quantitative parametric maps remains unexplored, especially when comparing analog and digital signal pathways plus multiband. Here we report findings on quantitative T1 to assess the potential effect of scanner upgrades on qMRI. We found negligible differences, suggesting that T1 measurements remain stable following a major scanner upgrade.

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