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Abstract #3690

Mapping oxygen extraction fraction using a tailored parallel transmission RF pulse at 7 T

Yan Tong1, Peter Jezzard1, Caitlin O'Brien1, and William T Clarke1
1Wellcome Centre for Integrative Neuroimaging, FMRIB Division, NDCN, University of Oxford, Oxford, United Kingdom

T2‐relaxation under‐spin‐tagging (TRUST) is a robust spin tagging based method to quantify oxygen extraction fraction (OEF), but it lacks spatial specificity. Recently O’Brien et al. proposed a method involving multiple saturation pulses to achieve spatial specificity. Parallel transmission (pTx) provides additional degrees of freedom for spatial localisation. A pTx RF pulse design strategy based on a shells trajectory is applied to perform regional OEF measurement at 7 T. Initial in-vivo results acquired from one healthy subject showed that spatial localisation of OEF could be achieved.

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