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Abstract #3695

Optimization of adiabatic pulses for Pulsed ASL at 7T – Comparison with Pseudo-continuous ASL

Kai Wang1, Xingfeng shao1, Lirong Yan1, Jin Jin1,2,3, and Danny Wang1
1Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA, United States, 2School of Information Technology and Electrical Engineering, The University of Queensland,, Brisbane, Australia, 3ARC Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, Brisbane, Australia

The goal of this work was to optimize and evaluate four types of adiabatic pulses for pulsed ASL (PASL) at 7T including Hyperbolic Secant (HS), WURST, FOCI and trFOCI pulses using theoretical simulation, phantom and in vivo scans, and compare them with pseudo-continuous ASL (pCASL). PASL with WURST pulse outperformed PASL with HS, FOCI and trFOCI in terms of labeling efficiency and residual signal, and also showed higher labeling efficiency compared with pCASL, and thus is recommended for 7T perfusion measurement.

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