DWI is valuable for diagnosing diseases such as stroke and brain tumor. The traditional single-shot EPI is widely used in DWI because of its high acquisition speed, but it suffers from severe geometric distortions. A recently proposed technique, point-spread-function encoded EPI (PSF-EPI) that is highly accelerated by tilted-CAIPI, can achieve fast distortion-free DWI images on 3T scanners with a 32-channel head coil. This study investigated the feasibility of tilted-CAIPI accelerated PSF-EPI on a 1.5T clinical MRI scanner with an 8-channel head coil. Images with high anatomical fidelity and satisfactory SNR were obtained in 1~2.5 min using this technique.