Abstract #3739

Slice Accelerated EPI-based Magnetic Resonance Fingerprinting for Simultaneous Estimation of T1, T2, T2* with Whole-brain Coverage

Mahdi Khajehim^1,2, Thomas Christen³, Fred Tam⁴, Simon Graham^1,4, and J. Jean Chen^1,2

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Rotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada, ³Grenoble Institute of Neurosciences, Inserm, Grenoble, France, ⁴Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, ON, Canada

Magnetic resonance fingerprinting (MRF) offers a way to quantitatively estimate multiple relaxation parameters with a single scan, but fast MRF estimation of T1, T2, and T2* with a single acquisition remains challenging. Here, a dual-stage EPI-based MRF approach with online image reconstruction is proposed for estimating T1, T2, and T2*. We achieved 1.1x1.1x3 mm³ resolution with minimal distortion, and with the use of simultaneous multi-slice acceleration, our method can provide whole-brain coverage (1.7x1.7x3 mm³) in less than 3 minutes.

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