Tailored MRF (TMRF) provides scheme to acquire non-synthetic, multi contrast images simultaneously in one sequence by tailoring the acquisition scheme derived in MRF. Natural contrast obtained from TMRF overcomes artifacts observed in MRF such as flow and errors in tissue parameter quantitation. We acquired TMRF and MRF data on the ISMRM/NIST phantom along with gold standard relaxometry data. We also acquired MRF and TMRF data for 5 volunteers and compared the natural and synthetic contrasts; and the relaxometric maps. The TMRF natural contrasts are similar to control experiments and do not contain flow artifacts found in synthetic contrasts.
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