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Abstract #3777

Ex vivo mapping of the cyto- and the myeloarchitecture of the human cerebral cortex using ultra-high field MRI (7T and 11.7T)

Raïssa Yebga Hot1,2, Alexandros Popov1,2, Justine Beaujoin1, Gaël Perez1,3, Fabrice Poupon1,2, Igor Lima Maldonado4, Jean-François Mangin1,2, Christophe Destrieux4, and Cyril Poupon1,2
1CEA - NeuroSpin, Gif-sur-Yvette, France, 2Université Paris-Saclay, Orsay, France, 3CentraleSupélec, Gif-sur-Yvette, France, 4Imaging and Brain laboratory (iBrain), Université de Tours - INSERM, Tours, France

The investigation of the human cerebral cortex at the mesoscopic scale remains challenging but promising to better understand brain pathologies associated with cortex damage. In this ex vivo study, samples of occipital cortex from both hemispheres of an unique subject have been delineated using their microstructural and myeloarchitectural information inferred from ultra-high field anatomical, quantitative and diffusion MRI. The high-resolved UHF-MRI dataset enabled to perform an automatic segmentation of the cortical layers within the primary and secondary visual cortices. The segmentations highlighted their commonalities and differences between the two hemispheres.

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