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Abstract #3802

Faster Myelin water mapping by joint reconstruction and estimation from highly undersampled 3D-MSE acquisitions.

Riwaj Byanju1, Stefan Klein1, and Dirk H. J. Poot1
1Department of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, Netherlands

Myelin water fractions (MWF) can provide biomarkers for many brain disorders. Multiple-spin-echo (MSE) is considered as gold standard for obtaining MWF. However, its clinical application is limited by its long acquisition time. Efficient undersampling and exploiting the redundancy in the contrast images of MSE can decrease the acquisition time. We propose a subspace based image reconstruction technique designed for reconstructing contrast images from highly undersampled MSE acquisition, so that it can be used for MWF mapping. We evaluate it for different signal-to-noise ratios for up to acceleration factor of 16 and show its feasibility for accelerating acquisition beyond parallel imaging.

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