Abstract #3829

Improving breath-hold cerebrovascular reactivity mapping with multi-echo BOLD fMRI

Stefano Moia¹, Maite Termenon¹, Eneko Uruñuela-Tremiño¹, Rachael C. Stickland², Molly G. Bright^2,3, and César Caballero-Gaudes¹

¹Basque Center on Cognition Brain and Language, San Sebastián, Spain, ²Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, ³Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL, United States

Cerebrovascular reactivity (CVR) is an emerging metric for quantifying vascular health. During a BOLD fMRI acquisition, breath-holding is a simple approach for increasing blood CO₂ levels, thereby driving the vasodilatory CVR response. However, breath-holding is associated with increased head motion artifacts, which can confound our estimates of CVR. We demonstrate that multi-echo BOLD fMRI acquisitions, in conjunction with denoising with multi-echo independent component analysis approaches, enable better differentiation of true vasodilatory responses and improve the reliability of CVR estimates across multiple sessions in highly sampled individuals.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.