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Abstract #3829

Improving breath-hold cerebrovascular reactivity mapping with multi-echo BOLD fMRI

Stefano Moia1, Maite Termenon1, Eneko Uruñuela-Tremiño1, Rachael C. Stickland2, Molly G. Bright2,3, and César Caballero-Gaudes1
1Basque Center on Cognition Brain and Language, San Sebastián, Spain, 2Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, 3Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL, United States

Cerebrovascular reactivity (CVR) is an emerging metric for quantifying vascular health. During a BOLD fMRI acquisition, breath-holding is a simple approach for increasing blood CO2 levels, thereby driving the vasodilatory CVR response. However, breath-holding is associated with increased head motion artifacts, which can confound our estimates of CVR. We demonstrate that multi-echo BOLD fMRI acquisitions, in conjunction with denoising with multi-echo independent component analysis approaches, enable better differentiation of true vasodilatory responses and improve the reliability of CVR estimates across multiple sessions in highly sampled individuals.

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