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Abstract #3838

Characteristics of temporal dynamics of intrinsic brain activity in unmedicated bipolar II disorder with suicidality

JiaYing Gong1,2, Guanmao Chen1, Yanbin Jia3, Long Qian4, Li Huang1, and Ying Wang1
1Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China, 2Department of Radiology, Six Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 3Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou, China, 4MR Research, GE Healthcare, Beijing, China

The alterations of brain dynamics in bipolar disorder (BD) with suicidality are still unknown. Dynamic amplitude of low-frequency fluctuations (dALFF) was evaluated using sliding window analysis, and the severity of suicidality was predicted using a multivariate regression model between 106 BD II participants. Our findings suggest that alterations of temporal variability in the precuneus/ posterior cingulate cortex (PCC) is a common feature of BD participants, the right temporal lobe involved in impulsivity, social and emotional processing are associated with suicidality in BD II depression

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