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Abstract #3841

Cross vendor harmonization of water-extraction-phase-contrast-arterial-spin-tagging (WEPCAST) MRI for blood brain barrier assessment

Zixuan Lin1, Dengrong Jiang1, Zachary Baker1, Dapeng Liu1, Yang Li1, Xirui Hou1, Jay J. Pillai1, Qin Qin1, Yulin Ge2, and Hanzhang Lu1
1Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 2Department of Radiology, New York University Langone Medical Center, New York, NY, United States

Water-extraction-with-phase-contrast-arterial-spin-tagging (WEPCAST) MRI was proposed recently as a non-invasive technique to assess blood-brain barrier (BBB) permeability to water. However, the reproducibility of this technique and cross-vendor reliability has not been reported. In this study, we harmonized WEPCAST technique across two major MRI vendors, Philips and Siemens and examined the test-retest reproducibility of the technique. The results showed that WEPCAST MRI can give a reliable assessment of BBB permeability with an excellent reproducibility.

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