Abstract #3841

Cross vendor harmonization of water-extraction-phase-contrast-arterial-spin-tagging (WEPCAST) MRI for blood brain barrier assessment

Zixuan Lin¹, Dengrong Jiang¹, Zachary Baker¹, Dapeng Liu¹, Yang Li¹, Xirui Hou¹, Jay J. Pillai¹, Qin Qin¹, Yulin Ge², and Hanzhang Lu¹

¹Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, ²Department of Radiology, New York University Langone Medical Center, New York, NY, United States

Water-extraction-with-phase-contrast-arterial-spin-tagging (WEPCAST) MRI was proposed recently as a non-invasive technique to assess blood-brain barrier (BBB) permeability to water. However, the reproducibility of this technique and cross-vendor reliability has not been reported. In this study, we harmonized WEPCAST technique across two major MRI vendors, Philips and Siemens and examined the test-retest reproducibility of the technique. The results showed that WEPCAST MRI can give a reliable assessment of BBB permeability with an excellent reproducibility.

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