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Abstract #3844

Amplitude of slow fluctuations in CSF as a time-resolved marker of sleep states for resting-state fMRI: a validation study.

Javier Gonzalez-Castillo1, Daniel A Handwerker1, and Peter A Bandettini1,2
1Section on Functional Imaging Methods, NIMH, Bethesda, MD, United States, 2FMRI Facility, NIH, Bethesda, MD, United States

Wakefulness fluctuations during rest are a key confound for dynamic functional connectivity. Yet, tracking such fluctuations is not trivial when lacking concurrent EEG and/or eye-tracking. Recent work suggests that ultra-slow CSF fluctuations accompany descent into sleep. Here we evaluate how such fluctuations help track wakefulness in rest scans acquired on non sleep-deprived subjects using sequences not optimized for detecting such inflow-related fluctuations. We conclude that those fluctuations can be easily detected in other samples, and that they may provide valuable time-resolved information about fluctuations in wakefulness, as well as a means to segregate subjects according to their overall wakefulness levels.

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