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Abstract #3876

Functional line-scanning in humans with ultra-high spatiotemporal resolution: reconstruction and BOLD sensitivity assessment

Luisa Raimondo1, Tomas Knapen1,2, ĺcaro A.F. de Oliveira1, Xin Yu3,4, Serge O. Dumoulin1,5, Wietske van der Zwaag1, and Jeroen C.W Siero1,6
1Spinoza Centre for Neuroimaging, Amsterdam, Netherlands, 2VU University, Amsterdam, Netherlands, 3Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 4Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, SC, United States, 5Experimental and Applied Psychology, VU University, Amsterdam, Netherlands, 6Radiology, University Medical Centre Utrecht, Utrecht, Netherlands

We present initial results of line-scanning fMRI in humans. The potential of this technique lies in the combination of both high spatial and temporal resolution while sacrificing spatial coverage outside the region of interest. We reached a 250 μm resolution along the line direction with a temporal resolution of 200 ms. Coil sensitivity profiles and the average tSNR per channel were used to optimize the line reconstructions. We obtained similar BOLD sensitivity compared to standard 2D GE-EPI BOLD and high spatial specificity for a visual task. Hence, we demonstrate the feasibility of ultra-high spatiotemporal resolution in humans using line-scanning.

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