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Abstract #3881

Segmented spin-echo BOLD fMRI using a variable flip angle FLEET acquisition with recursive RF pulse design for high spatial resolution fMRI

Avery JL Berman1,2, William A Grissom3, Thomas Witzel1,2, Daniel J Park1, Olivia Viessmann1,2, Kawin Setsompop1,2,4, and Jonathan R Polimeni1,2,4
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Department of Radiology, Harvard Medical School, Boston, MA, United States, 3Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, 4Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

Spin-echo (SE) EPI has long been desired for fMRI acquisitions with reduced macrovascular sensitivity; however, to achieve a purely T2-weighted signal, requires sampling a short window around the spin-echo—generally achieved by a segmented readout. Segmented EPI is well-known to be temporally unstable due to sensitivity to subject motion between segments. Here we propose a reordering of the EPI segments, known as FLEET, combined with a variable flip angle excitation to maximize the image signal level and a recursive RF pulse design to maintain consistent slice profiles at the spin-echo. We demonstrate the feasibility of this approach at 3T.

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