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Abstract #3905

Negative correlations of brain activation between daily recognition and trauma memory remembering in PTSD

Kayako Matsuo1,2, Jun Inoue3, Toshiki Iwabuchi4, and Hidenori Yamasue5
1Center for Research Collaboration and Support, Dokkyo Medical University, Tochigi, Japan, 2Department of Psychiatry, Hamamatsu University School of Medicine (former), Hamamatsu, Japan, 3Department of Child and Adolescent Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan, 4Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan, 5Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan

We found a negative correlation between brain activity estimates of two conditions, daily recognition and trauma memory remembering, that reflected altered responses in PTSD. We conducted two task-fMRI runs for 9 patients with PTSD and the matched controls employing a script-driven imagery task. A region-of-interest analysis revealed a negative correlation between a hyperarousal subscale of psychological assessment and the activity estimate in the hippocampus in the daily recognition whereas a positive correlation in the trauma memory remembering. When computing voxel-based correlations between the activity estimates of the two conditions, extensive negative correlations emerged around the hippocampus in patients.

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