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Abstract #3907

Assessing somatotopic and mototopic organisation in Focal Hand Dystonia using high-resolution 7T-fMRI

Michael Asghar1, Daisie Pakenham1, Rosa Sanchez-Panchuelo1, Denis Schluppeck2, Paul Glover1, Miles Humberstone3, George O'Neill4, and Susan Francis1
1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2Psychology, University of Nottingham, Nottingham, United Kingdom, 3Nottingham Trust University Hospitals, University of Nottingham, Nottingham, United Kingdom, 4Wellcome Centre for Human Neuroimaging, UCL, London, United Kingdom

Six patients with Focal Hand Dystonia (FHD) were scanned at 7T both 4 weeks and 3 months after Botox treatment, along with age-matched healthy controls (HCs). Behaviourally, spatial acuity was raised in the FHD patients compared to HCs. Travelling wave fMRI data were collected to assess somatotopy and mototopy. Compared to age-matched healthy controls and a healthy probabilistic atlas, FHD patients show little difference in somatotopy. Spatial overlap of digits was not found to be significantly different between FHD patients and HCs. In both groups there was high spatial overlap of somatosensory and motor responses in the post-central gyrus.

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