Cerebrovascular reactivity (CVR) is typically measured from changes in cerebral perfusion responsive to a hypercapnic gas challenge. Recently, a real-time PC MRI technique using highly undersampled radial FLASH acquisitions with regularized nonlinear inversion reconstruction has been developed and showed great promise in quantifying CBF-based CVR during resting-state without hypercapnic gas challenge. However, quantification of CVR using this method requires optimization. In the present work, using the regular PC MRI as the gold standard, we compared four different analysis methods of the real-time PC MRI results, in order to identify the optimal approach for accurate CVR quantification using real-time PC MRI.
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