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Abstract #3911

Towards accurate quantification of cerebrovascular reactivity using real-time phase-contrast MRI

Wenqi Zhou1, Kristyna Herman1, Dengrong Jiang1, Hanzhang Lu1, and Peiying Liu1
1Johns Hopkins University School of Medicine, Baltimore, MD, United States

Cerebrovascular reactivity (CVR) is typically measured from changes in cerebral perfusion responsive to a hypercapnic gas challenge. Recently, a real-time PC MRI technique using highly undersampled radial FLASH acquisitions with regularized nonlinear inversion reconstruction has been developed and showed great promise in quantifying CBF-based CVR during resting-state without hypercapnic gas challenge. However, quantification of CVR using this method requires optimization. In the present work, using the regular PC MRI as the gold standard, we compared four different analysis methods of the real-time PC MRI results, in order to identify the optimal approach for accurate CVR quantification using real-time PC MRI.

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