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Abstract #3922

Mapping the brain-wide network effects by optogenetic activation of the corpus callosum with an MRI-guided robotic arm

Yi Chen1,2, Filip Sobczak1,2, Patricia Roldán Pais1,2, Cornelius Schwarz3, Alan P. Koretsky4, and Xin Yu1,5
1Research Group of Translational Neuroimaging and Neural Control, High-field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 2Graduate School of Neural Information Processing, University of Tübingen, Tübingen, Germany, 3Werner Reichardt Center for Integrative Neuroscience, Tübingen, Germany, 4Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, 5Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States

This study not only specifies the optogenetically driven corpus callosum-mediated regulation of the local excitation/inhibition balance in the local barrel cortex, but also depicts the power of the multi-modal fMRI to characterize the brain-wide network activity associated with circuit-specific optogenetic activations. It highlights a vital aspect of the brain-wide activation for circuit-specific causality studies with optogenetic tools.

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