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Abstract #3924

How brain reacts to attack at a hub region

Wenyu Tu1, Zilu Ma2, Yuncong Ma2, and Nanyin Zhang2
1The Huck Institutes of the Life Sciences, Penn State University, University Park, PA, United States, 2Biomedical Engineering, Penn State University, University Park, PA, United States

The brain function is a network phenomenon. However, exactly how brain network reconfigures when a brain region stops functioning is virtually unknown. By combining chemogenetic and resting-state fMRI methods in an awake rats, we investigated the causal impact of inactivating a hub region, dorsal anterior cingulate cortex on brain network properties. We found that disrupting hub activity changed organization of the default-mode network (DMN) and DMN-related behavior. It also altered topological architecture of the whole-brain network. Our study established a system that allows for mechanistically dissecting the relationship between local regions and the whole brain network organization.

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