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Abstract #3955

Effect of Eyeblink Conditioning on Intrinsic Brain Connectivity in Awake Rabbits: a resting-state fMRI study

Nicola Bertolino1, Daniele Procissi1, John F Disterhoft2, and Craig Weiss2
1Radiology, Northwestern University, Chicago, IL, United States, 2Physiology, Northwestern University, Chicago, IL, United States

Functional brain plasticity is an important characteristic of the brain and enables an individual to learn and adapt as a result of life experiences. In this study we investigated the reorganization of functional brain networks after eyeblink conditioning in awake rabbits by resting state fMRI. This work builds the foundation for studying pre-clinically how cognitive impairment affects learning processes, its implication on brain capability to adapt and learn, and the possible impact of new therapies.

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