Abstract #3968

Functional Connectivity in Limbic System May Determine the Laterality in Temporal Lobe Epilepsy- A Graph-Theory Approach

Saba Amiri¹, Jafar Mehvari Habibabadi², Seyed Sohrab Hashemi-Fesharaki³, Neda Mohammadi Mobarakeh¹, Mehdi Mirbagheri¹, and Mohammad-Reza Nazem-Zadeh^1,4

¹Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of), ²Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran (Islamic Republic of), ³Pars Advanced Medical Research Center, Pars Hospital, Tehran, Iran (Islamic Republic of), ⁴Research Center for Molecular and Cellular Imaging, Advanced Medical Technologies and Equipment Inst, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of)

Temporal lobe epilepsy (TLE) is a disorder of altered brain networks. We evaluated the functional connectivity of the brain limbic system believed to be affected by TLE, based on resting state functional MRI and the graph network analysis. Our results showed that insula, posterior cingulate gyrus, and thalamus may undergo abnormal functional connectivity in terms of local degree in both right and left TLE compared to the healthy subjects. Furthermore, our results suggest that functional connectivity, as evaluated by local degree in insula and thalamus may have a potential application to help determine the laterality in cases of TLE.

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