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Abstract #3970

The Study of Regional Homogeneity and dynamic functional Connectivity of Trigeminal Neuralgia at Resting-state fMRI

pengfei zhang1, jun wang1, shaoyu wang2, and jing zhang1
1LanZhou University Second Hospital, LanZhou, China, 2MR Scientific Marketing, ShangHai, China

Based on rest-state fMRI, we investigated the changes of regional neural activity in trigeminal Neuralgia (TN) patients via analysis of regional homogeneity (ReHo). Furthermore, the alterations of dynamic functional connectivity was explored. Compared with healthy controls , brain regions with significant ReHo value changes in TN patients are mainly concentrated in default mode network (DMN) and Ventral attention Network(VAN). Dynamic analysis suggested four distinct connectivity ‘States’ across the entire group. Our results demonstrated that TN is associated with abnormal neuronal activities in different areas of the brain and dynamic functional connectivity between functional networks.

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