Based on rest-state fMRI, we investigated the changes of regional neural activity in trigeminal Neuralgia (TN) patients via analysis of regional homogeneity (ReHo). Furthermore, the alterations of dynamic functional connectivity was explored. Compared with healthy controls , brain regions with significant ReHo value changes in TN patients are mainly concentrated in default mode network (DMN) and Ventral attention Network(VAN). Dynamic analysis suggested four distinct connectivity ‘States’ across the entire group. Our results demonstrated that TN is associated with abnormal neuronal activities in different areas of the brain and dynamic functional connectivity between functional networks.