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Abstract #3991

Different States of Dynamic Changes in Brain Functional Network Connectivity in Patients with Obsessive-compulsive Disorder

Hailong Li1, Xinyu Hu1, Xuan Bu1, Yingxue Gao1, Lianqing Zhang1, Lu Lu1, Shi Tang1, Yanlin Wang1, Yanchun Yang2, Qiyong Gong1, and Xiaoqi Huang1
1Huaxi MR Research Center (HMRRC), Functional and molecular imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University, Chengdu, China, 2Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, China

This study explored the temporal variability of functional connectivity among the brain networks in obsessive-compulsive disorder (OCD) patients. First, dynamic analysis suggested four distinct connectivity states. Relative to controls, OCD patients showed more frequent and larger-scale within and between-network connectivity changes at state II, whereas less frequent and smaller-scale between-network connectivity alterations appeared at state I and IV. Second, this study suggested a new network dysconnectivity model between SMN, DMN, cerebellum and visual network for OCD patients. These findings demonstrated the dynamic changes of brain network connectivity patterns in OCD, providing a new insight into OCD-related brain functional network alterations.

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