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Abstract #3993

Functional connectivity during spontaneous migraine attacks compared to pain-free periods: a resting-state fMRI study

Raquel Pestana Araújo1, Patrícia Figueiredo1, Joana Pinto1, Pedro Vilela2, Isabel Pavão Martins3, and Raquel Gil-Gouveia2
1ISR-Lisboa/LARSyS and Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal, 2Hospital da Luz, Lisboa, Portugal, 3Department of Clinical Neurosciences, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal

Migraine is a severe neurological brain condition of cyclical nature, with intermittent attacks alternating with attack-free periods. In this work, we studied a group of patients with episodic migraine without aura during a spontaneous migraine attack and during a pain-free period, using BOLD resting-state fMRI. Results showed decreases in functional connectivity (FC) within a sensorimotor-insular cortex network and a left frontoparietal/executive control network. These FC changes were correlated with the attack duration and the pain intensity of the ongoing attack, respectively.

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