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Abstract #4016

Voxel-wise Characterization of Hemodynamic Response Function in Brain White Matter Using Resting-State fMRI

Ting Wang1,2, D. Mitchell Wilkes3, Muwei Li2,4, Xi Wu1, John C. Gore2,4,5, and Zhaohua Ding2,3,5
1Department of Computer Science, Chengdu University of Information Technology, Chengdu, China, 2Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 3Electrical Engineering & Computer Science, Vanderbilt University, Nashville, TN, United States, 4Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 5Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

This study investigated the hemodynamic response function (HRF) of BOLD effects in white matter (WM) voxels obtained from fMRI in a resting-state. It was found that the WM HRF can be derived by reference to GM avalanche activities. The derived resting-state WM HRFs have low magnitudes, delayed onsets, and prolonged initial dips compared with GM HRF. The time delay distribution patterns and correlation coefficient profiles for WM voxels depend on the selection of the reference GM region. These findings suggest that fMRI signals in WM are associated with those in GM and encode neural activities.

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