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Abstract #4121

Focused Ultrasound Enhances Connectivity of Default Mode Network in Rat Brain

Chia-Yu Huang1, Yi-Cheng Wang1, Wen-Yen Chai2, Sheng-Min Huang1, Hao-Li Liu2, and Fu-Nien Wang1
1National Tsing Hua University, Hsinchu, Taiwan, 2Chang Gung University, Taoyuan, Taiwan

Focused ultrasound is a noninvasive, deep-penetrating, and spatially well-defined modality to modulate the neural activity. In this study, we used resting state functional MRI (rs-fMRI) to investigate the functionally connectivity after stimulation in the brain. Rats underwent focused ultrasound stimulation targeted unilaterally to the ventral posteromedial and ventral posterolateral thalamic nuclei (VPM/VPL) in the left thalamic region. The default mode network (DMN) showed hyper-correlation after sonication, and as time proceed, the correlation has a tendency to decline slowly in about 3 days.

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