Focused ultrasound is a noninvasive, deep-penetrating, and spatially well-defined modality to modulate the neural activity. In this study, we used resting state functional MRI (rs-fMRI) to investigate the functionally connectivity after stimulation in the brain. Rats underwent focused ultrasound stimulation targeted unilaterally to the ventral posteromedial and ventral posterolateral thalamic nuclei (VPM/VPL) in the left thalamic region. The default mode network (DMN) showed hyper-correlation after sonication, and as time proceed, the correlation has a tendency to decline slowly in about 3 days.
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