Abstract #4124

MR guided blood-brain-barrier opening induced by focus ultrasound on Non-human primate

Hui Zhou^1,2, Yang Liu³, Chao Zou¹, Xiaojing Long³, Xin Liu¹, and Hairong Zheng¹

¹Shenzhen Institutes of Advanced Technology，Chinese Academy of Sciences, Shenzhen, China, ²The Shenzhen College of Advanced Technology, University of Chinese Academy of Sciences, Shenzhen, China, ³Research center for medical AI, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

Magnetic Resonance Imaging(MRI) is highly recommended for estimation of the feasibility and safety of BBB opening. We opened BBB in three different deep brain areas of an non-human primate with a single element ultrasound transducer working at 300kHz without detectable edema, hemorrhage and abnormal behavior. We found that the BBB in gray matter was easier to be disrupted than that in white matter, suggesting that for a local BBB opening in deep brain on non-human primate and human subjects, array transduces with relative large assemble surface are required to avoid the BBB disruption in cerebral cortex.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.