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Abstract #4159

Whole Body PET/MRI Biodistribution of F-18 fluorobenzylamide doxorubicin in an Intra-arterial Procedure

Parth Kumar1, Caroline D. Jordan1, Joseph E. Blecha1, Thomas R. Hayes1, Carol Stillson1, Aaron D. Losey1, Eric Mastria1, Colin Yee1, Bridget F. Kilbride1, Teri Moore1, Mark W. Wilson1, Henry F. VanBrocklin1, and Steven W. Hetts1
1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States

Recent studies have shown effective use of intravascular filtration devices to remove chemotherapy drugs; however, accurate quantification of the drug’s distribution on the device, within the targeted organ, and systemically, is necessary. We synthesized 18F analog of doxorubicin, fluorobenzylamide doxorubicin ([18F]FB-Dox), which was administered via an intra-arterial catheter, without a filter, and imaged under PET/MRI in vivo. [18F]FB-Dox showed a measurable decrease in the liver, and an increase in the bladder, kidney, and gall bladder over a 90-minute period after injection. This demonstrates a viable way to assess and track the baseline biodistribution of an intra-arterial chemotherapy procedure.

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