Abstract #4272

Development of a Three-Compartment Spherical CEST and T1 Phantom for UHF Sequence Development and Testing

Ryan T Oglesby^1,2, Wendy Oakden², Wilfred W Lam², Agata Chudzik³, Katarzyna Kochalska³, Radoslaw Rola³, and Greg J Stanisz^1,2,3

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Sunnybrook Research Institute, Toronto, ON, Canada, ³Neurosurgery and Paediatric Neurosurgery, Medical University of Lublin, Lublin, Poland

The development of quantitative MRI sequences at ultra-high field (UHF) (7 T or higher) is difficult due to non-uniform RF fields, enhanced susceptibility artifacts, and increased SAR. Phantoms are required in order to test quantitative pulse sequences, and it becomes increasingly important that artifacts in phantoms be as similar as possible to those observed in vivo. In this study, a 3D printed three-compartment spherical phantom was designed to evaluate chemical exchange saturation transfer (CEST), magnetization transfer (MT), and T₁ mapping sequences on UHF MRI systems.

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