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Abstract #4272

Development of a Three-Compartment Spherical CEST and T1 Phantom for UHF Sequence Development and Testing

Ryan T Oglesby1,2, Wendy Oakden2, Wilfred W Lam2, Agata Chudzik3, Katarzyna Kochalska3, Radoslaw Rola3, and Greg J Stanisz1,2,3
1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Sunnybrook Research Institute, Toronto, ON, Canada, 3Neurosurgery and Paediatric Neurosurgery, Medical University of Lublin, Lublin, Poland

The development of quantitative MRI sequences at ultra-high field (UHF) (7 T or higher) is difficult due to non-uniform RF fields, enhanced susceptibility artifacts, and increased SAR. Phantoms are required in order to test quantitative pulse sequences, and it becomes increasingly important that artifacts in phantoms be as similar as possible to those observed in vivo. In this study, a 3D printed three-compartment spherical phantom was designed to evaluate chemical exchange saturation transfer (CEST), magnetization transfer (MT), and T1 mapping sequences on UHF MRI systems.

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