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Abstract #4277

High resolved 13C MRS of myo-Inositol C1-C6 in the human brain in vivo at 7T

Eulalia Serés Roig1 and Rolf Gruetter1,2,3
1Laboratory of Functional and Metabolic Imaging (LIFMET) - Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 2Centre d'Imagerie BioMédicale - Animal and Imaging Technology (CIBM-AIT) - Ecole Polytechnique de Lausanne (EPFL), Lausanne, Switzerland, 3Department of Radiology, Universities of Lausanne (UNIL) and Geneva (UNIGE), Lausanne, Switzerland

The quantification of metabolite signals in the 1H-spectrum of the human brain in vivo is complicated by an extensive spectral overlap of resonances, due to the restricted chemical shift dispersion of the 1H-nucleus. For instance, the myo-Inositol peaks observable in the 1H-spectrum at 7T are close the water resonance and overlap with that of glycine. In contrast, the high resolution of the 13C-MR spectrum aids in the interpretation of the highly sensitive but poorly resolved 1H-MR spectrum. In this study, we demonstrate the advantage of 13C-MRS at 7T by measuring high resolved myo-Inositol C1-C6 resonances in the human brain.

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