Abstract #4277

High resolved 13C MRS of myo-Inositol C1-C6 in the human brain in vivo at 7T

Eulalia Serés Roig¹ and Rolf Gruetter^1,2,3

¹Laboratory of Functional and Metabolic Imaging (LIFMET) - Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ²Centre d'Imagerie BioMédicale - Animal and Imaging Technology (CIBM-AIT) - Ecole Polytechnique de Lausanne (EPFL), Lausanne, Switzerland, ³Department of Radiology, Universities of Lausanne (UNIL) and Geneva (UNIGE), Lausanne, Switzerland

The quantification of metabolite signals in the ¹H-spectrum of the human brain in vivo is complicated by an extensive spectral overlap of resonances, due to the restricted chemical shift dispersion of the ¹H-nucleus. For instance, the myo-Inositol peaks observable in the ¹H-spectrum at 7T are close the water resonance and overlap with that of glycine. In contrast, the high resolution of the ¹³C-MR spectrum aids in the interpretation of the highly sensitive but poorly resolved ¹H-MR spectrum. In this study, we demonstrate the advantage of ¹³C-MRS at 7T by measuring high resolved myo-Inositol C₁-C₆ resonances in the human brain.

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