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Abstract #4291

Relationship between thrombus and aneurysm wall in partially thrombosed intracranial aneurysms visualized with 7T MPRAGE

Bixia Chen1,2, Taku Sato2,3, Oliver Gembruch1,2, Michael Forsting4, Alexander Radbruch4, Jan Rodemerk2, Shiqing He2, Stefan Maderwald1, Harald H. Quick1,5, Mark E. Ladd1,6, Ulrich Sure2, and Karsten H. Wrede1,2
1Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, Germany, 2Department of Neurosurgery, University Hospital Essen, University Duisburg-Essen, Essen, Germany, 3Department of Neurosurgery, Fukushima Medical University, Fukushima, Japan, 4Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany, 5High Field and Hybrid MR Imaging, University Hospital Essen, University Duisburg-Essen, Essen, Germany, 6Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

This in-vivo study aimed to investigate the relationship between thrombus characteristics and the aneurysm wall (AW) in partially thrombosed intracranial aneurysms (pTIAs) using MPRAGE at 7T MRI. The AWs with the highest signal intensity ratio of thrombus were significantly thicker. In the histopathological examinations, three cases with hypointensity of the thrombus showed only a few macrophages in the thrombus and a thin AW. Three cases with hyperintensity of the thrombus in the MPRAGE showed abundant macrophages in the thrombus. In 7T MPRAGE, the signal intensity ratio of thrombus in pTIAs correlates with AW thickness and histologic features indicating wall instability.

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