Abstract #4291

Relationship between thrombus and aneurysm wall in partially thrombosed intracranial aneurysms visualized with 7T MPRAGE

Bixia Chen^1,2, Taku Sato^2,3, Oliver Gembruch^1,2, Michael Forsting⁴, Alexander Radbruch⁴, Jan Rodemerk², Shiqing He², Stefan Maderwald¹, Harald H. Quick^1,5, Mark E. Ladd^1,6, Ulrich Sure², and Karsten H. Wrede^1,2

¹Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, Germany, ²Department of Neurosurgery, University Hospital Essen, University Duisburg-Essen, Essen, Germany, ³Department of Neurosurgery, Fukushima Medical University, Fukushima, Japan, ⁴Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany, ⁵High Field and Hybrid MR Imaging, University Hospital Essen, University Duisburg-Essen, Essen, Germany, ⁶Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

This in-vivo study aimed to investigate the relationship between thrombus characteristics and the aneurysm wall (AW) in partially thrombosed intracranial aneurysms (pTIAs) using MPRAGE at 7T MRI. The AWs with the highest signal intensity ratio of thrombus were significantly thicker. In the histopathological examinations, three cases with hypointensity of the thrombus showed only a few macrophages in the thrombus and a thin AW. Three cases with hyperintensity of the thrombus in the MPRAGE showed abundant macrophages in the thrombus. In 7T MPRAGE, the signal intensity ratio of thrombus in pTIAs correlates with AW thickness and histologic features indicating wall instability.

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