Abstract #4310

Clinical Microscopic Fractional Anisotropy Imaging in 4 Minutes: an Optimization Approach

Nico J. J. Arezza^1,2, Desmond H. Y. Tse², Aidin Arbabi², and Corey A. Baron^1,2

¹Medical Biophysics, Western University, London, ON, Canada, ²Center for Functional and Metabolic Mapping, Robarts Research Institute, London, ON, Canada

Microscopic diffusion anisotropy ($$$\mu A$$$) and microscopic fractional anisotropy ($$$\mu FA$$$) quantify water diffusion anisotropy in tissue with no influence from neuron fiber orientation. Here, we characterized $$$\mu A^2$$$ signal-to-noise ratio using standard error propagation to determine the b-value and ratio of linear to isotropic encodings needed to maximize image quality. This optimization enabled an MRI protocol that utilizes efficient isotropic diffusion encoding to acquire high-quality full-brain $$$\mu A^2$$$ and $$$\mu FA$$$ maps in 2.4 and 4 minutes, respectively, which are demonstrated in two healthy volunteers at 3T.

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