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Abstract #4310

Clinical Microscopic Fractional Anisotropy Imaging in 4 Minutes: an Optimization Approach 

Nico J. J. Arezza1,2, Desmond H. Y. Tse2, Aidin Arbabi2, and Corey A. Baron1,2
1Medical Biophysics, Western University, London, ON, Canada, 2Center for Functional and Metabolic Mapping, Robarts Research Institute, London, ON, Canada

Microscopic diffusion anisotropy ($$$\mu A$$$) and microscopic fractional anisotropy ($$$\mu FA$$$) quantify water diffusion anisotropy in tissue with no influence from neuron fiber orientation. Here, we characterized $$$\mu A^2$$$ signal-to-noise ratio using standard error propagation to determine the b-value and ratio of linear to isotropic encodings needed to maximize image quality. This optimization enabled an MRI protocol that utilizes efficient isotropic diffusion encoding to acquire high-quality full-brain $$$\mu A^2$$$ and $$$\mu FA$$$ maps in 2.4 and 4 minutes, respectively, which are demonstrated in two healthy volunteers at 3T.

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