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Abstract #4315

Intravoxel incoherent motion analysis of the brain with second-order motion-compensated diffusion encoding

Naoki Ohno1, Tosiaki Miyati1, Tetsuo Ogino2, Yu Ueda2, Yuki Koshino1,3, Yudai Shogan1,3, Toshifumi Gabata4, and Satoshi Kobayashi1
1Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan, 2Philips Japan, Tokyo, Japan, 3Radiology Division, Kanazawa University Hospital, Kanazawa, Japan, 4Department of Radiology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan

In this study, we compared diffusion parameters with intravoxel incoherent motion (IVIM) analysis of the brain between second-order motion-compensated (2nd-MC) and conventional (non-MC) diffusion encoding schemes. Perfusion-related diffusion coefficient with non-MC was strongly affected by bulk motion in the pons which has the largest motion in the brain. By contrast, the 2nd-MC diffusion gradients compensated the bulk motion-induced signal loss and improved the fitting accuracy of biexponential model. The 2nd-MC diffusion encoding reduces the bulk motion effect on IVIM analysis of the brain, thereby improving the measurement accuracy.

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