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Abstract #4347

Distortion Correction for Isotropic High-Resolution Diffusion Imaging Using 3D Simultaneous Multi-Slab (SMSlab) Acquisition

Simin Liu1, Yuhui Xiong1,2, Erpeng Dai1,3, Jieying Zhang1, and Hua Guo1
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 2Neusoft Medical Systems Co., Ltd., Shanghai, China, 3Department of Radiology, Stanford University, Stanford, CA, United States

In EPI-based diffusion imaging, the geometric distortions become more severe with increased image resolution. Various post-processing methods have been proposed to correct for distortions, such as the top-up method and the field-mapping method. Nonetheless, for 3D isotropic high-resolution diffusion imaging, distortion correction becomes more challenging due to decreased SNR. In this study, we applied a modified distortion correction method, which was previously proposed for 2D imaging, to isotropic high-resolution diffusion imaging using 3D simultaneous multi-slab (SMSlab) acquisition. The modified distortion correction method performed well in both phantom and in vivo experiments. It also outperformed the conventional top-up and field-mapping methods.

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