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Abstract #4361

SENSE reconstruction with simultaneous 2D phase correction and channel-wise noise removal (SPECTRE)

Elizabeth Powell1,2, Torben Schneider3, Marco Battiston2, Francesco Grussu2,4, Ahmed Toosy2, Jonathan D Clayden5, and Claudia A. M. Gandini Wheeler-Kingshott2,6,7
1Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 2NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 3Philips Healthcare, Guildford, United Kingdom, 4Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, 5Developmental Imaging and Biophysics Section, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom, 6Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, 7Brain MRI 3T Center, IRCCS Mondino Foundation, Pavia, Italy

Nyquist sampling errors in echo planar imaging (EPI) often require 2D phase correction during reconstruction to remove unwanted ghost artefacts; however, phase corrections can be challenging to translate to high b-value diffusion weighted imaging (DWI) owing to associated noise amplification. We introduce SPECTRE (SENSE with 2D PhasE CorrecTion and channel-wise noise REmoval), and demonstrate that the SNR gains achieved by denoising complex channel data enable robust ghost correction without biasing diffusion parameter estimates.

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