Quasi-diffusion image (QDI) is a new ultra-high b-value diffusion magnetic resonance imaging technique which provides standard and non-Gaussian diffusion images. We use permutation analysis to optimise a clinical QDI tensor acquisition from a gold standard multi b-value protocol (28 non-zero b-values in 6 diffusion directions) to identify a 2 minute acquisition protocol with excellent tissue contrast. We achieve this by comparing different b-value combinations (2 non-zero b-values) to the gold standard using χ2 difference in parameterised signal decay curves. We obtain an optimal acquisition protocol of b=0, 1080, 5000 s mm-2 that may be acquired in a clinically acceptable time.
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