Conventional $$$T_1$$$-mapping techniques are only sensitive to voxel-averaged $$$T_1$$$ values, which hinders the study of fiber-specific myelination changes in the developing, aging or diseased brain. While recent works have focused on combining diffusion- and $$$T_1$$$- weightings to access orientation-resolved $$$T_1$$$ values, they rely on assumptions regarding the voxel content. This work combines a prototype diffusion-relaxation MR acquisition and a Monte-Carlo inversion method to extract intra-voxel nonparametric 5D distributions of diffusion tensors and longitudinal relaxation rates $$$R_1=1/T_1$$$ without the use of limiting assumptions. Estimated $$$R_1$$$ values are then mapped onto nonparametric orientation distribution functions, thereby yielding fiber-specific longitudinal relaxation rates.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords