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Abstract #4411

Spatiotemporal evolution of ischemic lesions in stroke animal models using free-water elimination and mapping with explicit T2 modelling

Ezequiel Farrher1, Chia-Wen Chiang2, Kuan-Hung Cho2, Richard Buschbeck1, Ming-Jye Chen2, Zaheer Abbas1, Kuo-Jen Wu3, Yun Wang3, Farida Grinberg1, Chang-Hoon Choi1, N. Jon Shah1,4,5,6, and Li-Wei Kuo2,7
1INM-4, Forschungszentrum Jülich, Jülich, Germany, 2Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, Taiwan, 3Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan, 4Department of Neurology, RWTH Aachen University, Aachen, Germany, 5JARA – BRAIN – Translational Medicine, RWTH Aachen University, Aachen, Germany, 6Institute of Neuroscience and Medicine 11, JARA, Forschungszentrum Jülich, Jülich, Germany, 7Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan

It is known that excess fluid as a result of vasogenic oedema formation following stroke onset obscures the microstructural characterisation of ischemic tissue by diffusion MRI. DTI-based free water elimination and mapping (FWE) has been proposed as a technique to potentially reduce the partial-volume effect. However, FWE estimation is ill-conditioned, leading to inaccurate results. More recently, it has been shown that the addition of a second dimension spanned by transverse relaxation weighting, mitigates the ill-conditioned problem. We aim here to investigate the latter model in a longitudinal study of MCAo stroke animal models.

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