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Abstract #4414

Anomalous diffusion MRI model parameters vary in the human corpus callosum sub-regions with age

Qianqian Yang1 and Viktor Vegh2
1School of Mathematical Sciences, Queensland University of Technology, Brisbane, Australia, 2Centre for Advanced Imaging, University of Queensland, Brisbane, Australia

Diffusion MRI measures of the human brain provide key insight into microstructural variations across individuals and into the impact of central nervous system diseases and disorders. One approach to extract information from diffusion signals has been to use biologically relevant analytical models to link millimetre scale diffusion MRI measures with microscale influences. The other approach has been to represent diffusion as an anomalous process, and infer information from the different anomalous diffusion equation parameters. Here, we show how parameters of three established anomalous diffusion equations change with age, in a microstructurally complex tissue, the human corpus callosum.

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