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Abstract #4416

Exploring effects of membrane permeability on dMRI metrics with Analytical solutions and Monte Carlo simulations

Zihan Zhou1, Qiuping Ding1, Hongjian He1, and Jianhui Zhong1,2
1Center for Brain Imaging Science and Technology, Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrumental Science, Zhejiang University, Hangzhou, China, 2School of Medicine and Dentistry, University of Rochester Medical Center, New York, NY, United States

White Matter Tract Integrity (WMTI) is a biophysical model with specificity to underlying tissue microstructures. However, recent work has suggested that inter-compartmental water exchange may affect outcomes of the model metrics. In this work, we analytically relate the WMTI-derived dMRI metrics to membrane permeability, and validate our predictions using Monte Carlo simulations. Our results show that the water exchange has a non-trivial effect on the metrics and needs to be carefully considered in WMTI.

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