Abstract #4438

Using free waveform diffusion MRI to investigate time-dependence of water movement in an isotropic in vitro system

Daniel Djayakarsana^1,2, Gregory J Czarnota^1,2,3, and Colleen Bailey^1,2

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ³Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

Signal attenuation due to diffusion is affected by several different acquisition parameters, such as gradient duration, spacing, strength and shape. In this study, I used free waveforms to investigate the effect of non-rectangular pulses. I chose an isotropic in vitro system such that the signal represents time and spatial scales relevant to human imaging and is independent of orientation. By varying only the gradient shape to target certain q-space frequencies, the signal measured could represent different combinations of diffusion time.

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