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Abstract #4456

Scan-Rescan Reliability of Microstructural Imaging Metrics Derived from High-Gradient Diffusion MRI

Maya Polackal1, Qiyuan Tian1,2, Chanon Ngamsombat1,2,3, Aapo Nummenmaa1,2, Thomas Witzel1,2, Eric C. Klawiter2,4, Susie Y. Huang1,2,5, and Qiuyun Fan1,2
1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Department of Radiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Thailand, 4Department of Neurology, Massachusetts General Hospital, Boston, MA, United States, 5Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

Scan-rescan reliability of axon diameter index, restricted volume fraction, and DTI metrics derived from high-gradient diffusion MRI was assessed in seven healthy volunteers. Maps of all three metrics were visually comparable from scan/rescan sessions, and moderate to high voxel-wise correlation coefficients were obtained for all metrics. Intraclass correlation coefficients were high for well-defined white matter tracts across all subjects. Our preliminary findings support the robustness and reliability of high-gradient diffusion MR metrics for use in clinical research studies.

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