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Abstract #4473

What factor influences most the reproducibility of MRI-based white matter tract estimation using probabilistic tractography?

Irène Brumer1,2,3, Enrico De Vita1, Jonathan Ashmore2,4, Jozef Jarosz2, and Marco Borri2
1Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, 2Department of Neuroradiology, King’s College Hospital, London, United Kingdom, 3Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, 4Department of Medical Physics and Bioengineering, NHS Highland, Inverness, United Kingdom

MRI-based white matter tract estimation using probabilistic tractography is valuable for presurgical planning. In this work, we investigate three factors influencing the reproducibility of probabilistic tractography: the tract threshold used to visualise the analysis results in the final tractography image, the manually drawn seed region, and the end region of the tracts. A compromise between low risk and high reproducibility has to be found for the tract threshold. The end region definition was found to be the most important parameter for the inter-user reproducibility of restricted tracts. Good inter-user reproducibility for the unrestricted tracts is achievable for similar seed regions.

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