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Abstract #4491

Diffusion MRI simulation of realistic neurons with SpinDoctor and the Neuron Module

Van-Dang Nguyen1, Chengran Fang2,3, Demian Wassermann3, and Jing-Rebecca Li2
1Department of Computational Science and Technology, KTH Royal Institute of Technology, Stockholm, Sweden, 2INRIA-Saclay, Equipe DEFI, Palaiseau, France, 3INRIA Saclay, Equipe Parietal, Palaiseau, France

The dMRI simulation arising from realistic neurons can help investigate the cellular microstructure. Ensuring correct connectivity between distinct cellular compartments while minimizing the computational burden is one of the main challenges. The design of simulation algorithm and the construction of high-quality neuron meshes are crucial. The NeuronModule can perform HARDI simulation of realistic neurons at various b-values and diffusion sequences with high accuracy. The computational time per gradient-direction is around 30 seconds which is faster than some Monte-Carlo simulators. The linearity between the diffusion-direction-averaged signal and one over square root of b for tubular structures is validated by our simulations.

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