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Abstract #4510

Radiological Qualitative Assessment of IVIM Parameters for Total Variation Penalty Function Approach: A Pilot Study in Osteosarcoma

Amit Mehndiratta1, Esha Badiya Kayal1, Kedar Khare 2, Sameer Bakhshi3, Raju Sharma4, and Devasenathipathy Kandasamy4
1Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India, 2Department of Physics, Indian Institute of Technology Delhi, New Delhi, India, 3Dr. BRA Institute-Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India, 4Department of RadioDiagnosis, All India Institute of Medical Sciences, New Delhi, India

Radiological based qualitative assessment of evaluated IVIM parametric maps using state-of-the-art IVIM analysis methods Bi-exponential (BE) model with adaptive Total Variation Penalty function (BE+TV) and BE with adaptive Huber Penalty function (BE+HPF) has been performed in comparison to the commonly used IVIM analysis methodologies like BE model, and segmented BE methods. BE+TV/BE+HPF preserve spatial homogeneity in the parametric images by updating them iteratively during data fitting. Experimental results showed all IVIM analysis methods showed BE+TV and BE+HPF produced comparative better noise suppression and diagnostic quality and interpretability for D* and f than other methods.

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