Abstract #4514

Evaluation of longitudinal changes in white matter structural integrity and grey matter volume in Parkinson’s disease

Maurizio Bergamino¹, Elizabeth Keeling^1,2, Ryan R Walsh³, and Ashley M Stokes¹

¹Division of Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, ²Neuroscience Department, Arizona State University, Phoenix, AZ, United States, ³The Muhammad Ali Parkinson Center, Barrow Neurological Institute, Phoenix, AZ, United States

In this study, we investigated longitudinal changes in white matter (WM) structural integrity and gray matter (GM) volume in Parkinson’s disease (PD). More specifically, free-water diffusion tensor imaging (FW-DTI), generalized q-sampling imaging (GQI), and voxel-based morphometry (VBM) were assessed in data obtained from the Parkinson Progression Markers Initiative (PPMI) database. We hypothesize that the use of advanced DTI metrics and VBM analysis will improve the sensitivity and specificity for the detection of WM alterations and GM volumetric changes in PD over time.

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