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Abstract #4517

Quantification of uncertainty in parameterisations of cardiac myofibre orientations from diffusion-weighted imaging

Bianca Freytag1, Vicky Y Wang2, Alistair A Young3, and Martyn P Nash1
1Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand, 2Veterans Affairs Medical Center, San Francisco, CA, United States, 3Biomedical Engineering Department, King's College London, London, United Kingdom

Electro-mechanical models of heart function rely upon accurate representation of microstructural orientations in the myocardium. We assessed the sensitivity of a finite element parameterisation of the myofibre orientation field derived from high-resolution DWI data of a canine heart. Eigenanalysis of the indifference region in the neighbourhood of the optimal fit of the myofibre field enabled quantification of helix angle uncertainty consistent with the DWI data. This method can be used to propagate the uncertainty in myofibre parameterisation to electro-mechanics simulation results.

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